The Makhenes follows actress and musician Letoya Makhene as she balances being a mom, public figure, and spiritual healer. The show centers on her journey while exploring her family's drama - including her musician father Blondie, sisters Pauline and Gontse, and her kids.

"This isn't your typical celebrity reality show," Letoya says. "It's raw and honest. We're showing our family exactly as we are - real love, real pain, real life. I'm at my lowest point, and that's where our story begins."

The show follows Letoya as she balances her careers as an actress, musician, and healer while managing personal challenges like breakups and motherhood. 

Key family members include her father Blondie Makhene, a legendary South African musician and activist known for his unconventional parenting style; Gogo Lily, who provides family stability; sister Pauline, the eldest daughter dealing with mental health issues while caring for their 103-year-old grandmother; youngest sibling Gontse, who struggles with addiction; and Letoya's two children, Nubia and Tadiwa Jr., who are adjusting to their parents' divorce. The series explores complex family dynamics, personal struggles, healing processes, and the intricate relationships within this South African family across multiple generations.